RBM25 anticorps (Middle Region)

N° du produit ABIN5515107

Détail du produit anti-RBM25 anticorps

Antigène: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM25 est non-conjugé

Application: Western Blotting (WB)

Séquence: DRDRTKERDR DRDRERDRDR DRERSSDRNK DRSRSREKSR DRERERERER

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RBM25

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RBM25

Antigène: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Autre désignation: RBM25 (RBM25 Produits)

Synonymes: anticorps fi03e10, anticorps zgc:56208, anticorps wu:fi03e10, anticorps si:ch211-105d18.5, anticorps rnpc7, anticorps s164, anticorps NET52, anticorps RED120, anticorps RNPC7, anticorps S164, anticorps Snu71, anticorps fSAP94, anticorps 2600011C06Rik, anticorps 2610015J01Rik, anticorps A130095G20Rik, anticorps AI159652, anticorps AL023075, anticorps AU043498, anticorps RNA binding motif protein 25b, anticorps RNA binding motif protein 25, anticorps RNA binding motif protein 25 S homeolog, anticorps putative rna binding motif protein 25, anticorps rbm25b, anticorps Rbm25, anticorps rbm25.S, anticorps rbm25, anticorps RBM25, anticorps Smp_078610

Sujet: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Alias Symbols: S164, NET52, RNPC7, Snu71, RED120, fSAP94

Protein Size: 843

ID gène: 58517

NCBI Accession: NM_021239, NP_067062

UniProt: P49756