INPP5E anticorps (Middle Region)

N° du produit ABIN5516992

Détail du produit anti-INPP5E anticorps

Antigène: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5E est non-conjugé

Application: Western Blotting (WB)

Séquence: SLQEIPKSRG VLSSERGSPS SGGNPLSGVA SSSPNLPHRD AAVAGSSPRL

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human INPP5E

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur INPP5E

Antigène: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Autre désignation: INPP5E (INPP5E Produits)

Synonymes: anticorps 1200002L24Rik, anticorps 72kDa, anticorps mKIAA0123, anticorps CORS1, anticorps CPD4, anticorps JBTS1, anticorps MORMS, anticorps PPI5PIV, anticorps PMPCA, anticorps inositol polyphosphate-5-phosphatase E, anticorps Inpp5e, anticorps INPP5E

Sujet: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome, a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: CPD4, CORS1, JBTS1, MORMS, PPI5PIV

Protein Size: 610

ID gène: 56623

NCBI Accession: NM_019892, NP_063945