MASP1 anticorps (Middle Region)

N° du produit ABIN5517538

Détail du produit anti-MASP1 anticorps

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MASP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE

Attributs du produit: This is a rabbit polyclonal antibody against MASP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human MASP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MASP1

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Autre désignation: MASP1 (MASP1 Produits)

Synonymes: anticorps AW048060, anticorps CCPII, anticorps Crarf, anticorps Masp1/3, anticorps 3MC1, anticorps CRARF, anticorps CRARF1, anticorps MAP1, anticorps MASP, anticorps MASP3, anticorps MAp44, anticorps PRSS5, anticorps RaRF, anticorps mannan-binding lectin serine peptidase 1, anticorps mannan binding lectin serine peptidase 1, anticorps Masp1, anticorps MASP1

Sujet: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Alias Symbols: MASP1, CRARF, CRARF1, PRSS5,

Protein Interaction Partner: CDK19, CUL3, PDCD6IP, RPS6KA6, MAPK8IP2, NUDT21, NCK2, UFD1L, RPS6KA3, MAPK6, H2AFX, GSK3B, GADD45A, C2, SERPING1, FCN2, MBL2, C3, MASP2,

Protein Size: 380

ID gène: 5648

Pathways: Système du Complément