SPATA18 anticorps (Middle Region)

N° du produit ABIN5517765

Détail du produit anti-SPATA18 anticorps

Antigène: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPATA18 est non-conjugé

Application: Western Blotting (WB)

Séquence: ELKSLQAQED ARHRNTDQRS SENRRSEPWS LEERKREQWN SLKQNADQQD

Homologie: Cow: 77%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPATA18. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SPATA18

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SPATA18

Antigène: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Autre désignation: SPATA18 (SPATA18 Produits)

Synonymes: anticorps Mieap, anticorps SPETEX1, anticorps 1700067I02Rik, anticorps MIEAP, anticorps spetex-1, anticorps mieap, anticorps spetex1, anticorps im:7140046, anticorps zgc:110352, anticorps spermatogenesis associated 18, anticorps spermatogenesis associated 18 L homeolog, anticorps SPATA18, anticorps Spata18, anticorps spata18.L, anticorps spata18

Sujet: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

Alias Symbols: Mieap, SPETEX1

Protein Interaction Partner: PAXIP1,

Protein Size: 506

ID gène: 132671

NCBI Accession: NM_001297608, NP_001284537