This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This NR0B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human NR0B2.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antigène
NR0B2
(Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))
anticorps SHP, anticorps SHP1, anticorps SHP-1, anticorps Shp1, anticorps Shp, anticorps NR0B2-A, anticorps Nr0b2, anticorps SHP-A, anticorps gb:bc058069, anticorps nuclear receptor subfamily 0 group B member 2, anticorps nuclear receptor subfamily 0, group B, member 2, anticorps nuclear receptor subfamily 0, group B, member 2a, anticorps NR0B2, anticorps Nr0b2, anticorps nr0b2a
Sujet
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.