TRIB1 anticorps (C-Term)

N° du produit ABIN5532742

Détail du produit anti-TRIB1 anticorps

Antigène: TRIB1 (Tribbles Homolog 1 (TRIB1))

Épitope: AA 341-370, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIB1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogène: This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TRIB1

Antigène: TRIB1 (Tribbles Homolog 1 (TRIB1))

Autre désignation: TRIB1 (TRIB1 Produits)

Synonymes: anticorps TRIB1, anticorps c8fw, anticorps gig2, anticorps skip1, anticorps trb1, anticorps tribbles, anticorps C8FW, anticorps GIG2, anticorps SKIP1, anticorps TRB1, anticorps A530090O15Rik, anticorps TRB-1, anticorps Trb1, anticorps Gig2, anticorps tribbles pseudokinase 1, anticorps tribbles pseudokinase 1 L homeolog, anticorps tribbles homolog 1 (Drosophila), anticorps TRIB1, anticorps trib1, anticorps trib1.L, anticorps Trib1

Sujet: TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Poids moléculaire: 41 kDa

ID gène: 10221

UniProt: Q96RU8

Pathways: Smooth Muscle Cell Migration