PPID anticorps (AA 336-370)

N° du produit ABIN5533624

Détail du produit anti-PPID anticorps

Antigène: PPID (Peptidylprolyl Isomerase D (PPID))

Épitope: AA 336-370

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPID est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Cyclophilin D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 336-370 amino acids from the human region of human Cyclophilin D.

Isotype: Ig Fraction

Information d'application

Indications d'application: For FACS starting dilution is: 1:25

For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PPID

Antigène: PPID (Peptidylprolyl Isomerase D (PPID))

Autre désignation: Cyclophilin D (PPID Produits)

Synonymes: anticorps PPID, anticorps CYP-40, anticorps CYPD, anticorps Cyp-40, anticorps CypD, anticorps wu:fb18b07, anticorps zgc:86711, anticorps 4930564J03Rik, anticorps Ppidl, anticorps Ppif, anticorps cyp-40, anticorps cypd, anticorps peptidylprolyl isomerase D, anticorps peptidylprolyl isomerase D (cyclophilin D), anticorps peptidylprolyl isomerase D (cyclophilin D) S homeolog, anticorps PPID, anticorps Ppid, anticorps ppid, anticorps ppid.S

Sujet: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Poids moléculaire: 41 kDa

ID gène: 5481

UniProt: Q08752

Pathways: Nuclear Hormone Receptor Binding