Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antigène
ADAMTS13
(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13))
anticorps ADAMTS13, anticorps ADAM-TS13, anticorps ADAMTS-13, anticorps C9orf8, anticorps VWFCP, anticorps vWF-CP, anticorps Gm710, anticorps ADAM metallopeptidase with thrombospondin type 1 motif 13, anticorps a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13, anticorps ADAM metallopeptidase with thrombospondin type 1 motif, 13, anticorps ADAMTS13, anticorps Adamts13, anticorps adamts13
Sujet
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.