CPSF4 anticorps (AA 96-123)

N° du produit ABIN5533971

Détail du produit anti-CPSF4 anticorps

Antigène: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Épitope: AA 96-123

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPSF4 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CPSF4

Antigène: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Autre désignation: CPSF4 (CPSF4 Produits)

Synonymes: anticorps cpsf30, anticorps nar, anticorps neb1, anticorps 30kDa, anticorps C79664, anticorps CPSF30, anticorps NAR, anticorps NEB1, anticorps cleavage and polyadenylation specific factor 4, anticorps cleavage and polyadenylation specific factor 4, 30kDa, anticorps cleavage and polyadenylation specific factor 4 S homeolog, anticorps CPSF4, anticorps Cpsf4, anticorps LOC733099, anticorps LOC100360200, anticorps cpsf4.S, anticorps cpsf4

Sujet: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.

Poids moléculaire: 30 kDa

ID gène: 10898

UniProt: O95639