Kdm6b anticorps (AA 954-987)

N° du produit ABIN5536322

Détail du produit anti-Kdm6b anticorps

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Épitope: AA 954-987

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kdm6b est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogène: This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the Central region of mouse JMJD3.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Kdm6b

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Autre désignation: JMJD3 (Kdm6b Produits)

Synonymes: anticorps jmjd3, anticorps kdm6b, anticorps si:ch211-237l4.7, anticorps 1700064E03Rik, anticorps BC038313, anticorps Jmjd3, anticorps mKIAA0346, anticorps JMJD3, anticorps lysine (K)-specific demethylase 6B, anticorps lysine demethylase 6B, anticorps lysine (K)-specific demethylase 6B, b, anticorps KDM1 lysine (K)-specific demethylase 6B, anticorps kdm6b, anticorps KDM6B, anticorps kdm6bb, anticorps Kdm6b

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Poids moléculaire: 176 kDa

ID gène: 216850

UniProt: Q5NCY0

Pathways: L'effet Warburg