MBNL1 anticorps (C-Term)
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- Antigène Voir toutes MBNL1 Anticorps
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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Épitope
- AA 255-284, C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MBNL1 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product MBNL1 Anticorps primaire
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- Indications d'application
- For WB starting dilution is: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
- Autre désignation
- MBNL1 (MBNL1 Produits)
- Synonymes
- anticorps MBNL1, anticorps zgc:153954, anticorps Mbnl, anticorps mKIAA0428, anticorps EXP, anticorps EXP35, anticorps EXP40, anticorps EXP42, anticorps MBNL, anticorps muscleblind like splicing regulator 1, anticorps muscleblind-like splicing regulator 1, anticorps muscleblind like splicing factor 1, anticorps MBNL1, anticorps mbnl1, anticorps Mbnl1
- Sujet
- Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
- Poids moléculaire
- 42 kDa
- ID gène
- 4154
- UniProt
- Q9NR56
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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