SOS1 anticorps (AA 934-962)

N° du produit ABIN5537593

Cet anticorps anti-SOS1 est un anticorps Lapin Polyclonal détectant SOS1 dans WB et IHC (p). Adapté pour Humain.

Aperçu rapide pour SOS1 anticorps (AA 934-962) (ABIN5537593)

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SOS1 anticorps

Épitope: AA 934-962

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SOS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-962 amino acids from the Central region of human SOS1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SOS1

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Autre désignation: SOS1

Sujet: Son of Sevenless 1 protein is an activator of ras proteins by stimulating the exchange of GDP for GTP on ras. Murine Son of Sevenless proteins have been shown to form a complex with activated EGF receptor, coupling tyrosine kinases to ras proteins. The SOS gene was originally isolated in Drosophila. Two mammalian homologues (mSOS1 and mSOS2) have been isolated from a mouse cDNA library and are expressed in a variety of mouse embryo and adult tissues. Human SOS1 and SOS2 homologs have also been isolated. The two mouse homologs are approximately 70 % identical in composition. The mammalian SOS1 protein has a highly specific guanine nucleotide exchange activity towards p21ras. In epidermal growth factor stimulated cells, SOS1 interacts with SH3 domains of GRB2 and binds via SH2 domain to tyrosine 1068 of activated Epidermal Growth Factor receptor.

Poids moléculaire: 152 kDa

ID gène: 6654

UniProt: Q07889

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling