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NMDA 1 Receptor anticorps (pSer890)

NMDA R1 Reactivité: Humain, Rat, Souris IHC (p), IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5540835
  • Antigène Voir toutes NMDA 1 Receptor (NMDA R1) Anticorps
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Épitope
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer890
    Reactivité
    • 19
    • 16
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 18
    • 5
    Lapin
    Clonalité
    • 18
    • 5
    Polyclonal
    Conjugué
    • 23
    Cet anticorp NMDA 1 Receptor est non-conjugé
    Application
    • 19
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
    Purification
    Affinity chromatography using epitope-specific peptide
    Immunogène
    Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1 (KLH-conjugated)
    Top Product
    Discover our top product NMDA R1 Anticorps primaire
  • Indications d'application
    Immunohistochemistry on paraffin sections: 1:50~1:100. Immunofluorescence: 1:100~1:200.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
    Date de péremption
    12 months
  • Antigène
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Autre désignation
    nmda receptor 1 (NMDA R1 Produits)
    Synonymes
    anticorps CG2902, anticorps DMNMDAR1, anticorps DNMDAR-I, anticorps DNmdar, anticorps DmelNmdar1, anticorps Dmel\\CG2902, anticorps DrNR1, anticorps NMDA, anticorps NMDA R1, anticorps NMDAR1, anticorps NMdar1, anticorps NR1, anticorps NRI, anticorps Nmdar, anticorps dNR1, anticorps dnmdar-I, anticorps nmr, anticorps NMDA receptor 1, anticorps Nmdar1
    Sujet
    NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
    UniProt
    Q05586
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