EDNRB anticorps (Extracellular Domain, N-Term)

N° du produit ABIN5541800

Détail du produit anti-EDNRB anticorps

Antigène: EDNRB (Endothelin Receptor Type B (EDNRB))

Épitope: Extracellular Domain, N-Term

Reactivité: Humain, Chien, Singe, Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EDNRB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Detects N-terminal extracellular domain of Endothelin B Receptor (Family: GPCR Subfamily: Endothelin).

Purification: Peptide Immunogen Affinity Chromatography

Immunogène: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB

Information d'application

Indications d'application: Western Blot. Immunocytochemistry. Immunohistochemistry on Paraffin Embedded Sections : 4-11 μg/mL Antigen Retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-EDNRB (ABIN5541800)

Tanaka, Sho, Takayama, Wakatsuki, Matsumoto, Migita, Ito, Hamada, Nakajima: "Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma." dans: British journal of cancer, Vol. 110, Issue 4, pp. 1027-33, (2014) (PubMed).

Jones, Brockbank, Mobbs, Le Good, Soma-Haddrick, Heuze, Langham, Timms, Newham, Needham: "The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover." dans: Osteoarthritis and cartilage, Vol. 14, Issue 6, pp. 597-608, (2006) (PubMed).

Détails sur EDNRB

Antigène: EDNRB (Endothelin Receptor Type B (EDNRB))

Autre désignation: endothelin b receptor (EDNRB Produits)

Synonymes: anticorps ABCDS, anticorps ET-B, anticorps ET-BR, anticorps ETB, anticorps ETBR, anticorps ETRB, anticorps HSCR, anticorps HSCR2, anticorps WS4A, anticorps Ednra, anticorps Etb, anticorps ETR-b, anticorps ETb, anticorps Sox10m1, anticorps EDNRB, anticorps abcds, anticorps etb, anticorps etrb, anticorps hscr, anticorps hscr2, anticorps endothelin receptor type B, anticorps EDNRB, anticorps Ednrb, anticorps ednrb

Sujet: The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel.

UniProt: P24530

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process