TP53BP2 anticorps
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- Antigène Voir toutes TP53BP2 Anticorps
- TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
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Reactivité
- Humain, Chien, Macaque
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TP53BP2 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody is directed against ASPP2.
- Réactivité croisée (Details)
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Species reactivity (expected):Canine (100 %), Macaque (100 %), Mouse (80 %), Rat (80 %).
Species reactivity (tested):Human. - Purification
- Affinity Chromatography on Protein A
- Immunogène
- Synthetic peptide corresponding to an internal sequence of Human ASPP2 . Genename: ASPP2
- Isotype
- IgG
- Top Product
- Discover our top product TP53BP2 Anticorps primaire
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- Indications d'application
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ELISA: 1/2,500-1/10,000. Western Blot: 1/500-1/3,000. Expect a band approximately 125 kDa in size correspondingto ASPP2 in the appropriate cell lysate or extract.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 2.4 mg/mL (by UV absorbance at 280 nm)
- Buffer
- 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
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- Antigène
- TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
- Autre désignation
- TP53BP2 (TP53BP2 Produits)
- Synonymes
- anticorps 53BP2, anticorps ASPP2, anticorps BBP, anticorps P53BP2, anticorps PPP1R13A, anticorps TP53BP2, anticorps AI746547, anticorps Tp53bp2, anticorps X98550, anticorps Trp53bp2, anticorps wu:fa09h08, anticorps wu:fb04e08, anticorps zgc:85720, anticorps tumor protein p53 binding protein 2, anticorps tumor protein p53 binding protein 2 L homeolog, anticorps tumor protein p53 binding protein, 2b, anticorps transformation related protein 53 binding protein 2, anticorps tumor protein p53 binding protein, 2, anticorps tumor protein p53 binding protein, 2a, anticorps TP53BP2, anticorps tp53bp2.L, anticorps tp53bp2, anticorps tp53bp2b, anticorps Trp53bp2, anticorps Tp53bp2, anticorps tp53bp2a
- Sujet
- ASPP (ankyrinrepeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63-and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: 53BP2, ASPP2, Apoptosis-stimulating of p53 protein 2, BBP, Bcl2-binding protein, NY-REN-51, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2
- ID gène
- 7159
- NCBI Accession
- NP_001026855
- UniProt
- Q13625
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