GGCX anticorps (C-Term)

N° du produit ABIN452673

Détail du produit anti-GGCX anticorps

Antigène: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Épitope: C-Term

Reactivité: Humain, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp GGCX est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: GGCX antibody AP09596PU-N is expected to recognize both isoforms (NP_000812.2 and NP_001135741.1).

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence C-PPESNPDPVHSE, from the C-Terminus of the protein sequence according to NP_000812.2 and NP_001135741.1.

Information d'application

Indications d'application: Peptide ELISA: GGCX Antibody Detection limit dilution 1/32000. Western blot: 0.3-1 μg/mL. Approx 85 kDa band observed in Human Muscle lysates(calculated MW of 85 kDa according to NP_000812.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur GGCX

Antigène: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Autre désignation: GGCX (GGCX Produits)

Synonymes: anticorps GGCX, anticorps cb751, anticorps si:ch1073-230p18.3, anticorps zgc:158736, anticorps ggcx, anticorps GGC, anticorps vkcfd1, anticorps CG13927, anticorps DgammaC, anticorps Dmel\\CG13927, anticorps dGC, anticorps dgammaC, anticorps gammaC, anticorps VKCFD1, anticorps gamma-glutamyl carboxylase, anticorps gamma-glutamyl carboxylase L homeolog, anticorps GGCX, anticorps ggcx, anticorps GC, anticorps sce5891, anticorps ggcx.L, anticorps Ggcx

Sujet: Gamma-glutamyl carboxylase GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. GGCX accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]). These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP, MIM 112260) and bone matrix protein (MGP, MIM 154870).Synonyms: GC, Gamma-glutamyl carboxylase, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase

ID gène: 2677

NCBI Accession: NP_000812

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interactome