Ephrin B2 anticorps (Internal Region)

N° du produit ABIN499146

Détail du produit anti-Ephrin B2 anticorps

Antigène: Ephrin B2 (EFNB2)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin B2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: CPKVDSKTVG QYE

Specificité: Recognizes EFNB2

Réactivité croisée (Details): Species reactivity (expected):Canine, Bovine, Pig.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_004084.1. Genename: EFNB2

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.1-0.3 μg/mL. This antibody detects a band of approx. 35 kDa band observed inHuman, Mouse and Rat Lung lysates.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Ephrin B2

Antigène: Ephrin B2 (EFNB2)

Autre désignation: Ephrin-B2 (EFNB2 Produits)

Synonymes: anticorps EFNB2, anticorps efnb2, anticorps ephrin-B2, anticorps htkl, anticorps eplg5, anticorps htk-l, anticorps lerk5, anticorps ephrinB2, anticorps efnb2a, anticorps MGC68890, anticorps efnb2b, anticorps ELF-2, anticorps Epl5, anticorps Eplg5, anticorps Htk-L, anticorps LERK-5, anticorps Lerk5, anticorps NLERK-1, anticorps EPLG5, anticorps HTKL, anticorps LERK5, anticorps ephrin B2, anticorps ephrin-B2 precursor, anticorps ephrin B2 L homeolog, anticorps ephrin B2 S homeolog, anticorps EFNB2, anticorps efnb2, anticorps efnb2.L, anticorps efnb2.S, anticorps Efnb2

Sujet: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP)and also interacts with PRKCABP and GRIP1. This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. Ephrin-B2 also binds EphA4, EphB1, EphB2, EphB3 and EphB4. Ephrin-B2 can be detected on monocytes, mesangial cells, CD34+ stem cells, bone marrow fibroblasts, activated melanocytes and melanoma cells, and pre-artery endothelial cells.Synonyms: EFNB2, EPH-related receptor tyrosine kinase ligand 5, EPLG5, HTK ligand, HTK-L, HTKL, LERK-5, LERK5

Poids moléculaire: 36.9kDa (NP_004084.1)

ID gène: 1948

NCBI Accession: NP_004084

UniProt: P52799

Pathways: Signalisation RTK, Regulation of Muscle Cell Differentiation