Recombinant CD40L (Ruplizumab Biosimilar) anticorps

N° du produit ABIN5564228

Détail du produit anti-CD40L (Ruplizumab Biosimilar) anticorps

Antigène: CD40L (Ruplizumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Chien

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40L (Ruplizumab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)

Specificité: Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.

Réactivité croisée: Chien, Humain

Réactivité croisée (Details): Cross-reacts with canine CD40L.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.001EU/μg

Immunogène: Recombinant human CD40L.

Clone: Hu5c8

Isotype: IgG1

Information d'application

Commentaires:

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

Date de péremption: 12 months

Détails sur CD40L (Ruplizumab Biosimilar)

Antigène: CD40L (Ruplizumab Biosimilar)

Abstract: CD40L (Ruplizumab Biosimilar) Produits

Synonymes: anticorps CD154, anticorps CD40L, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TNFSF5, anticorps TRAP, anticorps gp39, anticorps hCD40L, anticorps CD40 ligand, anticorps CD40LG

Classe de substances: Biosimilar

Sujet: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

UniProt: P29965