Fibronectin anticorps

N° du produit ABIN5564237

Détail du produit anti-Fibronectin anticorps

Antigène: Fibronectin

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Poulet, Chien, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibronectin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Functional Studies (Func)

Specificité: Recognizes an epitope located in the EDA sequence of human cellular fibronectin (FN).

Réactivité croisée: Poulet, Boeuf (Vache), Chien, Humain, Singe, Souris, Porc, Rat (Rattus)

Aucune reactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): Does not detect extracellular FN (plasma FN). Cross-reacts with mouse, rat, monkey, pig, dog, cow and chicken fibronectin EDA (according to literature). Cross-reacts with mouse, rat, monkey, pig, dog, cow and chicken fibronectin EDA (according to literature).

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.001EU/μg purified protein (LAL test, Lonza).

Immunogène: Recombinant Extra Domain A (EDA) region of human cellular fibronectin.

Clone: IST-9

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In 20 mM sodium phosphate buffer, pH 7.6 containing 150 mM sodium chloride.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur Fibronectin

Antigène: Fibronectin

Abstract: Fibronectin Produits

Synonymes: anticorps FN, anticorps cig, anticorps fibronectin, anticorps finc, anticorps lets, anticorps msf, anticorps CIG, anticorps ED-B, anticorps FINC, anticorps FNZ, anticorps GFND, anticorps GFND2, anticorps LETS, anticorps MSF, anticorps E330027I09, anticorps Fn, anticorps Fn-1, anticorps FIBNEC, anticorps fn-1, anticorps fibronectin 1, anticorps FN1, anticorps fn1, anticorps Fn1

Sujet: Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.