TLR10 anticorps (AA 100-369)

N° du produit ABIN5564256

Détail du produit anti-TLR10 anticorps

Antigène: TLR10 (Toll-Like Receptor 10 (TLR10))

Épitope: AA 100-369

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR10 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Protein G purified.

Immunogène: Recombinant human TLR10 protein (aa 100-369).

Clone: ABM3C85

Isotype: IgG2a

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.05 % BSA and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.

Date de péremption: 12 months

Détails sur TLR10

Antigène: TLR10 (Toll-Like Receptor 10 (TLR10))

Autre désignation: TLR10 (TLR10 Produits)

Synonymes: anticorps TLR10, anticorps CD290, anticorps toll like receptor 10, anticorps toll-like receptor 10, anticorps TLR10, anticorps Tlr10

Sujet: TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1beta specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades