Huntingtin anticorps (Internal Region, pSer421)

N° du produit ABIN5596736

Détail du produit anti-Huntingtin anticorps

Antigène: Huntingtin (HTT)

Épitope: Internal Region, pSer421

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with human based on 100% sequence homology. Cross-reactivity with Huntington pS421 from other sources has not been determined.

Purification: Anti-Huntington pS421 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S421 residue.

Immunogène:

Immunogen: Anti-Huntington pS421 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region of human Huntingtin protein.

Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application:

Application Note: Anti-HTT antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~350 kDa corresponding to the appropriate cell lysate or extract.

Western Blot Dilution: 1 μg/mL

ELISA Dilution: 1: 10,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.07 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: Huntington (HTT Produits)

Synonymes: anticorps HTT, anticorps hd, anticorps ZHD, anticorps CG9995, anticorps Dmel\\CG9995, anticorps HD, anticorps Hsap\\HD, anticorps Htt, anticorps dHtt, anticorps dhtt, anticorps SLC6A4, anticorps huntington, anticorps it15, anticorps htt, anticorps IT15, anticorps AI256365, anticorps C430023I11Rik, anticorps Hd, anticorps Hdh, anticorps huntingtin, anticorps HTT, anticorps htt, anticorps LOC373520, anticorps Htt

Sujet:

Synonyms: Huntington disease protein, HTT, HD, IT15, HD protein, huntingtin, huntingtin (Huntington disease), IT15HD

Background: Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington's disease protein is ~350kD in size and is localized in the brain. Anti-Huntington antibody is ideal for investigators interested in Neuroscience research.

Gene Name: HTT

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport