RPS6KA1 anticorps (C-Term)

N° du produit ABIN5596747

Détail du produit anti-RPS6KA1 anticorps

Antigène: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPS6KA1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): A BLAST analysis was used to suggest cross reactivity with RSK1 proteins from human, rat and mouse. Partial reactivity may occur against RSK2 and RSK3 but has not been tested. Reactivity against homologues from other sources is not known.

Purification: This affinity-purified antibody is directed against the human RSK1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogène:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-terminal region of human RSK1 protein.

Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application:

Application Note: This affinity purified antibody has been tested for use in ELISA, western blot, and immunoprecipitation. Specific conditions for reactivity should be optimized by the end user. Expect a predominant band approximately 88 kDa in size corresponding to RSK1 by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1:200 - 1:1000

ELISA Dilution: 1:2,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer:

Buffer: 0.1 M Tris Chloride, 0.5 M Sodium Chloride, pH 8.0

Stabilizer: 50 % (v/v) Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur RPS6KA1

Antigène: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Autre désignation: p90 RSK1 (RPS6KA1 Produits)

Synonymes: anticorps HU-1, anticorps MAPKAPK1A, anticorps RSK, anticorps RSK1, anticorps Rsk1, anticorps p90rsk, anticorps rsk, anticorps RPS6KA, anticorps hu-1, anticorps mapkapk1a, anticorps rsk1, anticorps wu:fc56h07, anticorps zgc:152654, anticorps ribosomal protein S6 kinase A1, anticorps ribosomal protein S6 kinase polypeptide 1, anticorps ribosomal protein S6 kinase A1-like, anticorps ribosomal protein S6 kinase A1 L homeolog, anticorps ribosomal protein S6 kinase a, polypeptide 1, anticorps RPS6KA1, anticorps Rps6ka1, anticorps RPS6KA1L, anticorps rps6ka1.L, anticorps rps6ka1

Sujet:

Synonyms: 90 kDa ribosomal protein S6 kinase 1 antibody, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody, dJ590P13.1 antibody, EC 2.7.11.1 antibody, HU 1 antibody

Background: RSK1 is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsk's appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK1 is studied in cancer research and is known to inactive tumor supressor complexes and death kinases.

Gene Name: RPS6KA1, RSK1

ID gène: 6195

UniProt: Q15418

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades