HMGB1 anticorps (AA 1-215)

N° du produit ABIN561281

L’anticorps Souris Monoclonal anti-HMGB1 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter HMGB1 dans des échantillons de Humain. Il y a 5+ publications disponibles.

Aperçu rapide pour HMGB1 anticorps (AA 1-215) (ABIN561281)

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HMGB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1D5

Détail du produit anti-HMGB1 anticorps

Épitope: AA 1-215

Fonction: Mouse monoclonal antibody raised against a full length recombinant HMGB1.

Séquence: MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: HMGB1 (AAH03378.1, 1 a.a. ~ 215 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-HMGB1 (ABIN561281)

Ko, Hsu, Hsieh, Lien, Lee, Kou: "High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers." dans: Respirology (Carlton, Vic.), Vol. 19, Issue 2, pp. 253-61, (2014) (PubMed).

Demoulin, Herfs, Somja, Roncarati, Delvenne, Hubert: "HMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells." dans: International journal of cancer. Journal international du cancer, (2014) (PubMed).

Hirano, Yoshioka, Yunoue, Fujio, Yonezawa, Niiro, Habu, Oyoshi, Sugata, Kamezawa, Arimura, Hanaya, Tokimura, Tokudome, Arita: "TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6." dans: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 6, pp. 628-37, (2012) (PubMed).

Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: "Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3390-5, (2009) (PubMed).

Kijanka, Hector, Kay, Murray, Cummins, Murphy, MacCraith, Prehn, Kenny: "Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer." dans: Gut, Vol. 59, Issue 1, pp. 69-78, (2009) (PubMed).

Détails sur HMGB1

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: HMGB1

Sujet: Full Gene Name: high-mobility group box 1
Synonyms: DKFZp686A04236,HMG1,HMG3,SBP-1

ID gène: 3146

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome