SQSTM1 anticorps (AA 1-440)

N° du produit ABIN563860

Cet anticorps Souris Monoclonal détecte spécifiquement SQSTM1 dans WB, IF et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 88+ publications.

Aperçu rapide pour SQSTM1 anticorps (AA 1-440) (ABIN563860)

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SQSTM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Clone: 2C11

Détail du produit anti-SQSTM1 anticorps

Épitope: AA 1-440

Fonction: Mouse monoclonal antibody raised against a full length recombinant SQSTM1.

Séquence: MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL

Réactivité croisée: Humain, Souris

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: SQSTM1 (AAH03139.1, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-SQSTM1 (ABIN563860)

Korwitz, Merkwirth, Richter-Dennerlein, Tröder, Sprenger, Quirós, López-Otín, Rugarli, Langer: "Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria." dans: The Journal of cell biology, Vol. 212, Issue 2, pp. 157-66, (2016) (PubMed).

Sydow, Hochgräfe, Könen, Cadinu, Matenia, Petrova, Joseph, Dennissen, Mandelkow: "Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD." dans: Acta neuropathologica communications, Vol. 4, pp. 17, (2016) (PubMed).

Winner, Beard, Hassiotis, Lau, Luck, Hopwood, Hemsley: "A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome." dans: Human gene therapy, Vol. 27, Issue 5, pp. 363-75, (2016) (PubMed).

He, Hamm, Reddy, Sams, Peliciari-Garcia, McGinnis, Bailey, Chow, Rowe, Chatham, Young: "Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism." dans: American journal of physiology. Heart and circulatory physiology, Vol. 310, Issue 11, pp. H1520-32, (2016) (PubMed).

Jin, Hong, Park, Chang, Hong, Park, Lee: "Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors." dans: Scientific reports, Vol. 6, pp. 28945, (2016) (PubMed).

Aydinlik, Erkisa, Cevatemre, Sarimahmut, Dere, Ari, Ulukaya: "Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line." dans: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 49-57, (2016) (PubMed).

Redmann, Benavides, Berryhill, Wani, Ouyang, Johnson, Ravi, Barnes, Darley-Usmar, Zhang: "Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons." dans: Redox biology, Vol. 11, pp. 73-81, (2016) (PubMed).

Garofalo, Iovine, Kuryk, Capasso, Hirvinen, Vitale, Yliperttula, Bevilacqua, Cerullo: "Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity." dans: Molecular cancer therapeutics, Vol. 15, Issue 4, pp. 651-60, (2016) (PubMed).

Morgan, Thorburn: "Measuring Autophagy in the Context of Cancer." dans: Advances in experimental medicine and biology, Vol. 899, pp. 121-43, (2016) (PubMed).

Wilson, Nikolic, Kentish, Shalini, Hatzinikolas, Page, Dorstyn, Kumar: "Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice." dans: Cell death discovery, Vol. 2, pp. 16009, (2016) (PubMed).

Conlon, Thomas, Fedotova, Hernandez-Ono, Di Paolo, Chan, Ruggles, Gibeley, Liu, Ginsberg: "Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis." dans: The Journal of clinical investigation, Vol. 126, Issue 10, pp. 3852-3867, (2016) (PubMed).

de Luxán-Delgado, Caballero, Potes, Rubio-González, Rodríguez, Gutiérrez-Rodríguez, Solano, Coto-Montes: "Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation." dans: Journal of pineal research, Vol. 56, Issue 2, pp. 126-33, (2015) (PubMed).

Niso-Santano, Malik, Pietrocola, Bravo-San Pedro, Mariño, Cianfanelli, Ben-Younès, Troncoso, Markaki, Sica, Izzo, Chaba, Bauvy, Dupont, Kepp, Rockenfeller, Wolinski, Madeo, Lavandero, Codogno, Harper et al.: "Unsaturated fatty acids induce non-canonical autophagy. ..." dans: The EMBO journal, (2015) (PubMed).

Kucukgul, Ozler, Inci, Karakas, Irmak, Gozuacik, Taralp, Koc: "3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells." dans: Biotechnology and bioengineering, Vol. 112, Issue 4, pp. 811-21, (2015) (PubMed).

Li, Shi, He, Hu, Wang, Zhang, Chan, Chen: "Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells." dans: PLoS ONE, Vol. 10, Issue 3, pp. e0122753, (2015) (PubMed).

Porta, Kwong, Trojanowski, Lee: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." dans: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, (2015) (PubMed).

Yang, Peng, Ni, Li, Shi, Ding, Fan: "Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0130953, (2015) (PubMed).

Dou, Xu, Donahue, Shimi, Pan, Zhu, Ivanov, Capell, Drake, Shah, Catanzaro, Ricketts, Lamark, Adam, Marmorstein, Zong, Johansen, Goldman, Adams, Berger: "Autophagy mediates degradation of nuclear lamina." dans: Nature, Vol. 527, Issue 7576, pp. 105-9, (2015) (PubMed).

Cinque, Forrester, Bartolomeo, Svelto, Venditti, Montefusco, Polishchuk, Nusco, Rossi, Medina, Polishchuk, De Matteis, Settembre: "FGF signalling regulates bone growth through autophagy." dans: Nature, Vol. 528, Issue 7581, pp. 272-5, (2015) (PubMed).

Tung, Wang, Hsu, Hu, Her, Huang, Liao: "Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation." dans: Molecular neurobiology, Vol. 49, Issue 1, pp. 10-27, (2014) (PubMed).

Détails sur SQSTM1

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Autre désignation: SQSTM1

Sujet: Full Gene Name: sequestosome 1
Synonyms: A170,OSIL,PDB3,ZIP3,p60,p62,p62B

ID gène: 8878

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy