TNFSF14 anticorps (Extracellular Domain)

N° du produit ABIN5688604

Détail du produit anti-TNFSF14 anticorps

Antigène: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF14 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: LIGHT Antibody is supplied as protein A purified IgG2b.

Immunogène: LIGHT antibody was raised against the extracellular domain of human LIGHT.

Clone: 8D4

Isotype: IgG2b

Information d'application

Indications d'application: LIGHT antibody can be used for detection of CD80 by Western blot at 0.5 - 1 μ,g/mL. LIGHT antibody can be used for immunohistochemistry starting at 2 - 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: LIGHT Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: LIGHT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TNFSF14

Antigène: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Autre désignation: LIGHT (TNFSF14 Produits)

Synonymes: anticorps TNFSF14, anticorps CD258, anticorps HVEML, anticorps LIGHT, anticorps LTg, anticorps TR2, anticorps HVEM-L, anticorps Ly113, anticorps TNF superfamily member 14, anticorps tumor necrosis factor (ligand) superfamily, member 14, anticorps TNFSF14, anticorps Tnfsf14

Sujet: LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation (1) and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells (1), LIGHT binding to LTβR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction (2). It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy (3), suggesting that LIGHT may become a potent tool in anti-cancer treatment.

Poids moléculaire: Predicted: 26 kDa

ID gène: 8740

NCBI Accession: NP_003798

UniProt: O43557

Pathways: Cancer Immune Checkpoints