ABL1/2 anticorps (AA 391-395, AA 427-231)

N° du produit ABIN5689521

Détail du produit anti-ABL1/2 anticorps

Antigène: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Épitope: AA 391-395, AA 427-231

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1/2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of total ABL1/2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: ABL1/2 (Ab-393/429) antibody was raised against a peptide sequence around aa.391~395/427~431 (D-T-Y-T-A) derived from ABL1/2 .

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur ABL1/2

Antigène: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Autre désignation: ABL1 / 2 (ABL1/ABL2 Produits)

Synonymes: anticorps CABL, anticorps ABLL, anticorps cb272, anticorps ABL proto-oncogene 2, non-receptor tyrosine kinase, anticorps c-abl oncogene 2, non-receptor tyrosine kinase, anticorps ABL2, anticorps abl2

Sujet: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Poids moléculaire: 135, 210 kDa

ID gène: 25, 27

NCBI Accession: NP_005148, NP_001129472

UniProt: P00519, P42684