PSMB9 anticorps (Internal Region)

N° du produit ABIN569589

Détail du produit anti-PSMB9 anticorps

Antigène: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Chien, Porc, Lapin, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMB9 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-RNISYKYRED

Specificité: Recognizes PSMB9

Réactivité croisée (Details): Species reactivity (expected):Mouse, Canine (Dog), Cow, Pig, Rabbit.
Species reactivity (tested):Human, Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_002791.1.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PSMB9

Antigène: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Autre désignation: PSMB9 (PSMB9 Produits)

Synonymes: anticorps LMP2, anticorps ring12, anticorps MHC-linked, anticorps psmb9b, anticorps lmp2, anticorps lmp2b, anticorps psmb9, anticorps Lmp-2, anticorps Lmp2, anticorps PSMB6i, anticorps RING12, anticorps beta1i, anticorps psmb9-A, anticorps macropain, anticorps prosome, anticorps wu:fa66f04, anticorps wu:fj22d05, anticorps zgc:91842, anticorps psmb9a, anticorps proteasome subunit beta 9, anticorps LMP2, anticorps proteasome subunit beta type-9b, anticorps proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), anticorps proteasome subunit beta 9 S homeolog, anticorps proteasome subunit beta 9a, anticorps proteasome (prosome, macropain) subunit, beta type, 9a, anticorps psmb9, anticorps PSMB9, anticorps psmb9-b, anticorps Psmb9, anticorps psmb9.S, anticorps psmb9a

Sujet: Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. LMP2 is a catalytic subunit of the 20S proteasome and, upon interferon gamma-induction, replaces the delta subunit. LMP2 alters the specificity of the 20S proteasome and is critical for the production of MHC class I ligands, production of T-lymphocytes, and is suggested to increase the efficiency of antigen presentation of the immune response. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).Synonyms: LMP2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, PSMB6i, Proteasome 20S LMP2, Proteasome chain 7, Proteasome subunit beta type-9, Proteasome subunit beta-1i, RING12, Really interesting new gene 12 protein

Poids moléculaire: 23.3kDa (Human NP_002791.1)

ID gène: 5698

NCBI Accession: NP_002791

UniProt: P28065

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA