HIC1 anticorps

N° du produit ABIN5697936

Détail du produit anti-HIC1 anticorps

Antigène: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: hypermethylated in cancer 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03857( HIC1 Antibody) at dilution of 1:1000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur HIC1

Antigène: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Autre désignation: HIC1 (HIC1 Produits)

Synonymes: anticorps zfHIC1, anticorps HIC1, anticorps ZBTB29, anticorps ZNF901, anticorps hic-1, anticorps AA408311, anticorps HIC-1, anticorps hypermethylated in cancer 1, anticorps HIC ZBTB transcriptional repressor 1, anticorps hic1, anticorps HIC1, anticorps Hic1

Sujet: Synonyms:ZBTB29 Background:Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Poids moléculaire: 65-70 kDa

ID gène: 3090

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus