DNA Helicase B anticorps

N° du produit ABIN5699254

Détail du produit anti-DNA Helicase B anticorps

Antigène: DNA Helicase B (HELB)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNA Helicase B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogène: helicase (DNA) B

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur DNA Helicase B

Antigène: DNA Helicase B (HELB)

Autre désignation: HELB (HELB Produits)

Synonymes: anticorps RGD1560103, anticorps hDHB, anticorps AI447783, anticorps D10Ertd664e, anticorps DNA helicase B, anticorps helicase (DNA) B, anticorps Helb, anticorps HELB

Sujet: Synonyms: Background:5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613).

Poids moléculaire: 120-140 kDa

ID gène: 92797

UniProt: Q8NG08