UBE2O anticorps

N° du produit ABIN5700803

Détail du produit anti-UBE2O anticorps

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2O est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: ubiquitin-conjugating enzyme E2O

Isotype: IgG

Information d'application

Indications d'application: WB : 1:200-1:2000

Commentaires:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09181(UBE2O antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur UBE2O

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Autre désignation: UBE2O (UBE2O Produits)

Synonymes: anticorps e2-230k, anticorps E2-230K, anticorps 9630022H21, anticorps B230113M03Rik, anticorps mKIAA1734, anticorps RGD1310297, anticorps ubiquitin conjugating enzyme E2 O, anticorps ubiquitin-conjugating enzyme E2O, anticorps UBE2O, anticorps ube2o, anticorps Ube2o

Sujet: Synonyms:E2-230K, FLJ12878, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O Background:E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins(PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity(PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis(PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal(NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location(PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853).

Poids moléculaire: 18kDa

ID gène: 63893

UniProt: Q9C0C9