NFKBIZ anticorps
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- Antigène Voir toutes NFKBIZ Anticorps
- NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NFKBIZ est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Immunogène
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
- Isotype
- IgG
- Top Product
- Discover our top product NFKBIZ Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))
- Autre désignation
- NFKBIZ (NFKBIZ Produits)
- Synonymes
- anticorps RGD1310834, anticorps NFKBIZ, anticorps MAIL, anticorps AA408868, anticorps INAP, anticorps Mail, anticorps IKBZ, anticorps NFKB inhibitor zeta, anticorps nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta, anticorps Nfkbiz, anticorps NFKBIZ, anticorps nfkbiz
- Sujet
- Synonyms:IKBZ, INAP, MAIL Background:Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis(By similarity).
- Poids moléculaire
- 64 kDa
- ID gène
- 64332
- UniProt
- Q9BYH8
- Pathways
- Signalisation NF-kappaB
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