USP10 anticorps

N° du produit ABIN5701378

Détail du produit anti-USP10 anticorps

Antigène: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogène: ubiquitin specific peptidase 10

Isotype: IgG

Information d'application

Indications d'application: WB : 1:500-1:5000,IP:1:200-1:2000,IF:1:10-1:100

Commentaires:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09304(USP10 antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur USP10

Antigène: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Autre désignation: USP10 (USP10 Produits)

Synonymes: anticorps T4F9.30, anticorps T4F9_30, anticorps ubiquitin-specific protease 9, anticorps ubpo, anticorps USP10, anticorps id:ibd1190, anticorps wu:fc19h08, anticorps wu:fc76g05, anticorps wu:fi11g01, anticorps UBPO, anticorps 2610014N07Rik, anticorps Uchrp, anticorps mKIAA0190, anticorps usp10-A, anticorps ubiquitin specific peptidase 10, anticorps universal stress protein UspA, anticorps ubiquitin-specific protease 9, anticorps ubiquitin carboxyl-terminal hydrolase 10, anticorps ubiquitin specific peptidase 10 S homeolog, anticorps USP10, anticorps RR_RS14970, anticorps UBP9, anticorps PTRG_07201, anticorps MGYG_06403, anticorps usp10, anticorps Usp10, anticorps usp10.S

Sujet: Synonyms:Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10 Background:Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989).

Poids moléculaire: 90kDa

ID gène: 9100

UniProt: Q14694