SLAMF7 anticorps

N° du produit ABIN5701905

Détail du produit anti-SLAMF7 anticorps

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLAMF7 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: SLAM family member 7

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur SLAMF7

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Autre désignation: SLAMF7 (SLAMF7 Produits)

Synonymes: anticorps RGD1560190, anticorps SLAMF7, anticorps slaf7, anticorps 19A, anticorps CD319, anticorps CRACC, anticorps CS1, anticorps 19A24, anticorps 4930560D03Rik, anticorps SLAM family member 7, anticorps Slamf7, anticorps SLAMF7, anticorps slaf7

Sujet: Synonyms:CS1 Background:Self-ligand receptor of the signaling lymphocytic activation molecule(SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway(PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K(PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells(By similarity). May play a role in lymphocyte adhesion(PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines(PubMed:23695528). Isoform 3 does not mediate any NK cell activation.

ID gène: 57823

UniProt: Q9NQ25