EXOSC10 anticorps

N° du produit ABIN5702156

Détail du produit anti-EXOSC10 anticorps

Antigène: EXOSC10 (Exosome Component 10 (EXOSC10))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogène: exosome component 10

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur EXOSC10

Antigène: EXOSC10 (Exosome Component 10 (EXOSC10))

Autre désignation: EXOSC10 (EXOSC10 Produits)

Synonymes: anticorps Pmscl2, anticorps zgc:55695, anticorps pm-scl, anticorps pm/scl-100, anticorps pmscl, anticorps pmscl2, anticorps rrp6, anticorps rrp6p, anticorps EXOSC10, anticorps 201.t00018, anticorps 21.m02990, anticorps DDBDRAFT_0203581, anticorps DDBDRAFT_0233752, anticorps DDB_0203581, anticorps DDB_0233752, anticorps PM-Scl, anticorps PM/Scl-100, anticorps PMSCL, anticorps PMSCL2, anticorps RRP6, anticorps Rrp6p, anticorps p2, anticorps p3, anticorps p4, anticorps exosome component 10, anticorps 3'-5' exonuclease, anticorps exosome component 10 L homeolog, anticorps exosc10, anticorps EXOSC10, anticorps EHI_021400, anticorps BBOV_IV002650, anticorps CpipJ_CPIJ003896, anticorps CMU_031760, anticorps Tsp_05247, anticorps exosc10.L, anticorps Exosc10

Sujet: Synonyms:PMSCL, PMSCL2, RRP6 Background:Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity(By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

ID gène: 5394

UniProt: Q01780