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MAP4K2 anticorps

MAP4K2 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5702938
  • Antigène Voir toutes MAP4K2 Anticorps
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Reactivité
    • 44
    • 28
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 56
    • 1
    Lapin
    Clonalité
    • 57
    Polyclonal
    Conjugué
    • 23
    • 6
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAP4K2 est non-conjugé
    Application
    • 47
    • 38
    • 13
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Immunogène
    mitogen-activated protein kinase kinase kinase kinase 2
    Isotype
    IgG
    Top Product
    Discover our top product MAP4K2 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze / thaw cycles.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Autre désignation
    MAP4K2 (MAP4K2 Produits)
    Synonymes
    anticorps BL44, anticorps GCK, anticorps RAB8IP, anticorps AI385662, anticorps Rab8ip, anticorps MAP4K2, anticorps dZ150L22.2, anticorps map4k2l, anticorps map4k2l-2, anticorps map4k3l, anticorps si:dz150l22.2, anticorps si:dz263j20.1, anticorps zgc:136670, anticorps mitogen-activated protein kinase kinase kinase kinase 2, anticorps mitogen activated protein kinase kinase kinase kinase 2, anticorps MAP4K2, anticorps Map4k2, anticorps LOC103346779, anticorps map4k2
    Sujet
    Synonyms:GCK, RAB8IP Background:Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase(MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase(SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns(PAMPs) such as polyinosine-polycytidine(poly(IC)), lipopolysaccharides(LPS), lipid A, peptidoglycan(PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
    Poids moléculaire
    85-91 kDa,58 kDa
    ID gène
    5871
    UniProt
    Q12851
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