Spt6 anticorps

N° du produit ABIN5703155

Détail du produit anti-Spt6 anticorps

Antigène: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spt6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogène: suppressor of Ty 6 homolog (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur Spt6

Antigène: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Autre désignation: SUPT6H (SUPT6H Produits)

Synonymes: anticorps SPT6, anticorps SPT6H, anticorps emb-5, anticorps 5131400N11Rik, anticorps AI132449, anticorps Supt6h, anticorps mKIAA0162, anticorps Spt6, anticorps wu:fj42h11, anticorps SUPT6H, anticorps spt6, anticorps spt6h, anticorps MGC146884, anticorps SPT6 homolog, histone chaperone, anticorps suppressor of Ty 6, anticorps SUPT6H,-like protein to suppressor of ty 6, anticorps transcription elongation factor SPT6, anticorps suppressor of Ty 6 homolog (S. cerevisiae), anticorps chromatin-remodeling histone chaperone, anticorps SUPT6H, anticorps Supt6, anticorps Supt6h, anticorps supt6h, anticorps LOC100092175, anticorps SPT6

Sujet: Synonyms:KIAA0162, SPT6H Background:Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II(RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase(AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

ID gène: 6830

UniProt: Q7KZ85

Pathways: Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response