CHMP1A anticorps
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- Antigène Voir toutes CHMP1A Anticorps
- CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CHMP1A est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogène
- chromatin modifying protein 1A
- Isotype
- IgG
- Top Product
- Discover our top product CHMP1A Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01656(CHMP1A antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
- Autre désignation
- CHMP1A (CHMP1A Produits)
- Synonymes
- anticorps CHMP1, anticorps PCH8, anticorps PCOLN3, anticorps PRSM1, anticorps VPS46-1, anticorps VPS46A, anticorps 2900018H07Rik, anticorps Pcoln3, anticorps charged multivesicular body protein 1A, anticorps CHMP1A, anticorps Chmp1a
- Sujet
- Synonyms:CHMP1, CHMP1A, chromatin modifying protein 1A, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1 Background:Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
- Poids moléculaire
- 33 kDa ,25 kDa
- ID gène
- 5119
- UniProt
- Q9HD42
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