CHM anticorps

N° du produit ABIN5708426

Détail du produit anti-CHM anticorps

Antigène: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHM est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogène: A recombinant human protein corresponding to amino acids A193-Q380 was used as the immunogen for the CHM antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CHM antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CHM antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur CHM

Antigène: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Autre désignation: CHM / Choroideremia protein (CHM Produits)

Synonymes: anticorps CHM, anticorps REP1, anticorps DXS540, anticorps GGTA, anticorps HSD-32, anticorps REP-1, anticorps TCD, anticorps DKFZp459K2154, anticorps tcd, anticorps ggta, anticorps rep-1, anticorps dxs540, anticorps hsd-32, anticorps MGC68578, anticorps Rep-1, anticorps chm, anticorps chm-a, anticorps chm-b, anticorps chml, anticorps CHM, Rab escort protein 1, anticorps choroideremia (Rab escort protein 1), anticorps choroideremia (Rab escort protein 1) L homeolog, anticorps choroidermia (RAB escort protein 1), anticorps choroideremia (Rab escort protein 1) S homeolog, anticorps CHM, anticorps chm, anticorps chm.L, anticorps Chm, anticorps chm.S

Sujet: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

UniProt: P24386

Pathways: Sensory Perception of Sound