TNFSF15 anticorps

N° du produit ABIN5708491

Détail du produit anti-TNFSF15 anticorps

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNFSF15 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: A recombinant human partial protein corresponding to amino acids L72-T244 was used as the immunogen for the TL1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TL1A antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA (Capture): 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the TL1A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur TNFSF15

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Autre désignation: TNFSF15 / VEGI / TL1A (TNFSF15 Produits)

Synonymes: anticorps TTPAL, anticorps TL1, anticorps TL1A, anticorps VEGI, anticorps VEGI192A, anticorps Tl1, anticorps Tl1a, anticorps Vegi, anticorps tumor necrosis factor superfamily member 15, anticorps TNF superfamily member 15, anticorps tumor necrosis factor (ligand) superfamily, member 15, anticorps TNFSF15, anticorps Tnfsf15

Sujet: Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy