TRPC4 anticorps

N° du produit ABIN571659

Détail du produit anti-TRPC4 anticorps

Antigène: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPC4 est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: Specific for TRPC4. See also the immunogen.

Immunogène: A synthetic peptide from human TRPC4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species.

Isotype: IgG

Information d'application

Indications d'application: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur TRPC4

Antigène: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Autre désignation: TRPC4 (TRPC4 Produits)

Synonymes: anticorps TRPC5, anticorps TRPC4, anticorps HTRP-4, anticorps HTRP4, anticorps TRP4, anticorps CCE1, anticorps STRPC4, anticorps Trp4, anticorps Trrp4, anticorps transient receptor potential cation channel subfamily C member 4, anticorps short transient receptor potential channel 4, anticorps transient receptor potential cation channel, subfamily C, member 4, anticorps TRPC4, anticorps LOC100538928, anticorps trpc4, anticorps Trpc4

Sujet: Function: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein. -
Tissue specificity: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer ofolfactory bulb). Lower levels are detected in other tissues. -
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. Also known as: Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4, hTrp-4, hTrp4.