HFE2 anticorps (AA 1-174)

N° du produit ABIN6141738

Détail du produit anti-HFE2 anticorps

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Épitope: AA 1-174

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HFE2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MQECIDQKVY QAEVDNLPVA FEDGSINGGD RPGGSSLSIQ TANPGNHVEI QAAYIGTTII IRQTAGQLSF SIKVAEDVAM AFSAEQDLQL CVGGCPPSQR LSRSERNRRG AITIDTARRL CKEGLPVEDA YFHSCVFDVL ISGDPNFTVA AQAALEDARA FLPDLEKLHL FPSD

Réactivité croisée: Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2 (NP_998817.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HFE2

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Autre désignation: HFE2 (HFE2 Produits)

Synonymes: anticorps HFE2A, anticorps HJV, anticorps JH, anticorps RGMC, anticorps HFE2, anticorps DKFZp468F2322, anticorps 2310035L15Rik, anticorps 5230400G09Rik, anticorps AI414844, anticorps AI789733, anticorps DL-M, anticorps Rgmc, anticorps hemojuvelin, anticorps RGMr, anticorps hjv, anticorps id:ibd3464, anticorps wu:fb38f10, anticorps zgc:136698, anticorps hemochromatosis type 2 (juvenile), anticorps hemochromatosis type 2, anticorps HFE2, anticorps Hfe2, anticorps hfe2

Sujet: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.,HFE2,HFE2A,HJV,JH,RGMC,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases Markers,Other Neurological disorders,Stem Cells,Amyotrophic lateral sclerosis-ALS,HFE2

Poids moléculaire: 21 kDa/33 kDa/45 kDa

ID gène: 148738

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis