IL23A anticorps

N° du produit ABIN614363

Détail du produit anti-IL23A anticorps

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL23A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Human recombinant p40 and p19 with elastin linker. The HLT2736 clone recognizes Human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a Capture antibody in ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Recombinant protein

Clone: HLT2736

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Références pour anticorps anti-IL23A (ABIN614363)

Botbol, Patel, Macian: "Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation." dans: Autophagy, Vol. 11, Issue 10, pp. 1864-77, (2015) (PubMed).

Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." dans: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, (2010) (PubMed).

Katsifis, Rekka, Moutsopoulos, Pillemer, Wahl: "Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis." dans: The American journal of pathology, Vol. 175, Issue 3, pp. 1167-77, (2009) (PubMed).

Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." dans: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, (2003) (PubMed).

Détails sur IL23A

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Autre désignation: Interleukin-23 alpha / IL23A (IL23A Produits)

Synonymes: anticorps IL-23, anticorps IL-23A, anticorps IL23P19, anticorps P19, anticorps SGRF, anticorps FIL1, anticorps FIL1(ZETA), anticorps FIL1Z, anticorps IL-1F7, anticorps IL-1H, anticorps IL-1H4, anticorps IL-1RP1, anticorps IL-37, anticorps IL1F7, anticorps IL1H4, anticorps IL1RP1, anticorps p19, anticorps il23p19, anticorps IL23, anticorps interleukin 23 subunit alpha, anticorps interleukin 37, anticorps interleukin 23, alpha subunit p19, anticorps IL23A, anticorps IL37, anticorps Il23a

Sujet: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

ID gène: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation