PSTPIP1 anticorps (AA 157-416)

N° du produit ABIN6146369

Détail du produit anti-PSTPIP1 anticorps

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Épitope: AA 157-416

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSTPIP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: AFERISANGH QKQVEKSQNK ARQCKDSATE AERVYRQSIA QLEKVRAEWE QEHRTTCEAF QLQEFDRLTI LRNALWVHSN QLSMQCVKDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT EPPAPVPYQN YYDREVTPLT SSPGIQPSCG MIKRFSGLLH GSPKTTSLAA SAASTETLTP TPERNEGVYT AIAVQEIQGN PASPAQEYRA LYDYTAQNPD ELDLSAGDIL EVILEGEDGW WTVERNGQRG FVPGSYLEKL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PSTPIP1

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Autre désignation: PSTPIP1 (PSTPIP1 Produits)

Synonymes: anticorps cd2bp1, anticorps cd2bp1l, anticorps cd2bp1s, anticorps h-pip, anticorps papas, anticorps pstpip, anticorps PSTPIP1, anticorps CD2BP1, anticorps CD2BP1L, anticorps CD2BP1S, anticorps H-PIP, anticorps PAPAS, anticorps PSTPIP, anticorps def-2, anticorps proline-serine-threonine phosphatase interacting protein 1, anticorps proline-serine-threonine phosphatase interacting protein 1 S homeolog, anticorps proline-serine-threonine phosphatase-interacting protein 1, anticorps PSTPIP1, anticorps pstpip1.S, anticorps pstpip1, anticorps Pstpip1

Sujet: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.,PSTPIP1,CD2BP1,CD2BP1L,CD2BP1S,H-PIP,PAPAS,PSTPIP,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,PSTPIP1

Poids moléculaire: 45 kDa/47 kDa

ID gène: 9051

UniProt: O43586