KIR2DL4/CD158d anticorps

N° du produit ABIN614805

Détail du produit anti-KIR2DL4/CD158d anticorps

Antigène: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIR2DL4/CD158d est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func), Immunofluorescence (IF)

Specificité: This Monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein-A Affinity Chromatography

Immunogène: NK3.3 cells and KIR2DL4-Ig fusion protein

Clone: MAb#33

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KIR2DL4/CD158d

Antigène: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Autre désignation: CD158d / KIR2DL4 (KIR2DL4 Produits)

Synonymes: anticorps G9P, anticorps CD158D, anticorps KIR103, anticorps KIR103AS, anticorps KIR2DL4, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4, anticorps killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4, anticorps KIR2DL4

Sujet: CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.Synonyms: CD158 antigen-like family member D, G9P, KIR103AS, Killer cell immunoglobulin-like receptor 2DL4, Killer cell inhibitory receptor 103AS, MHC class I NK cell receptor KIR103AS

ID gène: 3805

NCBI Accession: NP_001074239

UniProt: Q99706