VRK1 anticorps (AA 257-396)

N° du produit ABIN6150147

Détail du produit anti-VRK1 anticorps

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Épitope: AA 257-396

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VRK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: GHLPWEDNLK DPKYVRDSKI RYRENIASLM DKCFPEKNKP GEIAKYMETV KLLDYTEKPL YENLRDILLQ GLKAIGSKDD GKLDLSVVEN GGLKAKTITK KRKKEIEESK EPGVEDTEWS NTQTEEAIQT RSRTRKRVQK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 257-396 of human VRK1 (NP_003375.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur VRK1

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Autre désignation: VRK1 (VRK1 Produits)

Synonymes: anticorps vrk1, anticorps MGC64390, anticorps MGC75762, anticorps VRK1, anticorps PCH1, anticorps PCH1A, anticorps 51PK, anticorps wu:fe16f06, anticorps zgc:56266, anticorps vaccinia related kinase 1 L homeolog, anticorps vaccinia related kinase 1, anticorps Serine/threonine-protein kinase VRK1, anticorps vrk1.L, anticorps vrk1, anticorps VRK1, anticorps vrk-1, anticorps Vrk1

Sujet: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 Molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.,VRK1,PCH1,PCH1A,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,VRK1

Poids moléculaire: 45 kDa

ID gène: 7443

UniProt: Q99986