BIRC3 anticorps (Internal Region)

N° du produit ABIN615619

Détail du produit anti-BIRC3 anticorps

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Épitope: AA 109-118, Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-SQPTFPSSVT

Specificité: Recognizes BIRC3 (109-118)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_001156.1. Genename: BIRC3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BIRC3

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Autre désignation: IAP1 / BIRC3 (BIRC3 Produits)

Synonymes: anticorps AIP1, anticorps API2, anticorps CIAP2, anticorps HAIP1, anticorps HIAP1, anticorps MALT2, anticorps MIHC, anticorps RNF49, anticorps c-IAP2, anticorps Api1, anticorps Api2, anticorps IAP1, anticorps IAP2, anticorps MIHB, anticorps Birc2, anticorps HIAP2, anticorps MIAP1, anticorps MIAP2, anticorps cIAP1, anticorps cIAP2, anticorps cIAP-1, anticorps cIAP-2, anticorps AW107670, anticorps BIRC2, anticorps baculoviral IAP repeat containing 3, anticorps baculoviral IAP repeat-containing 3, anticorps baculoviral IAP repeat-containing protein 3, anticorps inhibitor of apoptosis protein-2, anticorps BIRC3, anticorps Birc3, anticorps LOC100399118, anticorps OpmnVgp074

Sujet: CIAP2 is an apoptotic suppressor. Apoptosis is triggered by a variety of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of cIAP (cIAP1 and cIAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The cIAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF alpha by its receptor. Omi, a negative regulator of cIAP, inhibits its activity by catalytically cleaving cIAP. Another negative regulator, Smac/DIABLO, acts by enhancing the autoubiquitization activity of cIAP.Synonyms: API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing protein 3, C-IAP2, HIAP-1, IAP homolog C, Inhibitor of apoptosis protein 1, MIHC, RING finger protein 49, RNF49, TNFR2-TRAF-signaling complex protein 1, cIAP2

ID gène: 330

NCBI Accession: NP_001156

UniProt: Q13489

Pathways: Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades