Desmoglein 1 anticorps (CF®488A)

N° du produit ABIN6162064

Détail du produit anti-Desmoglein 1 anticorps (CF®488A)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est conjugé à/à la CF®488A

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Fonction: Mouse Monoclonal anti-Desmoglein-1 (18D4), CF488A Conjugate

Attributs du produit: This antibody recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Human desmoglein-1 intracellular domain (exact sequence is proprietary)

Clone: 18D4

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow Cytometry 0.5-1 μg/million cells/0.1 mL

• Immunofluorescence 1-2 μg/mL
• Western blotting 0.5-1 μg/mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

A431 or A-375 cells. Skin

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: Desmoglein-1 (DSG1 Produits)

Synonymes: anticorps CDHF4, anticorps DG1, anticorps DSG, anticorps PPKS1, anticorps SPPK1, anticorps DSG-1, anticorps DSG1, anticorps Dsg1b, anticorps Dsg1c, anticorps desmoglein 1, anticorps desmoglein 4, anticorps DSG1, anticorps DSG4, anticorps Dsg1

Sujet: Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1

Poids moléculaire: 150 kDa (precursor), 160 kDa (mature)

ID gène: 1828, 2633

UniProt: Q02413

Pathways: Cell-Cell Junction Organization