Desmoglein 1 anticorps (CF®405S)
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- Antigène Voir toutes Desmoglein 1 (DSG1) Anticorps
- Desmoglein 1 (DSG1)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Desmoglein 1 est conjugé à/à la CF®405S
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Application
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Fonction
- Mouse Monoclonal anti-Desmoglein-1 (27B2), CF405S Conjugate
- Attributs du produit
- This antibody recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Human desmoglein-1 intracellular domain (exact sequence is proprietary)
- Clone
- 27B2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product DSG1 Anticorps primaire
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- Indications d'application
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Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Western blotting 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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A431 or A-375 cells. Skin
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
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- Antigène
- Desmoglein 1 (DSG1)
- Autre désignation
- Desmoglein-1 (DSG1 Produits)
- Synonymes
- anticorps CDHF4, anticorps DG1, anticorps DSG, anticorps PPKS1, anticorps SPPK1, anticorps DSG-1, anticorps DSG1, anticorps Dsg1b, anticorps Dsg1c, anticorps desmoglein 1, anticorps desmoglein 4, anticorps DSG1, anticorps DSG4, anticorps Dsg1
- Sujet
- Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1
- Poids moléculaire
- 150 kDa (precursor), 160 kDa (mature)
- ID gène
- 1828, 2633
- UniProt
- Q02413
- Pathways
- Cell-Cell Junction Organization
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