CD46 anticorps

N° du produit ABIN6187862

Détail du produit anti-CD46 anticorps

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Fonction: Mouse Monoclonal anti-CD46 (122.2), Purified, with BSA

Attributs du produit: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Purification: Purified

Immunogène: Recombinant human CD46 protein

Clone: 122-2

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

HeLa, K-562 or MOLT-4 cells. Kidney

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 200 μg/mL

Buffer: PBS/0.05 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur CD46

Antigène: CD46

Autre désignation: CD46 (CD46 Produits)

Synonymes: anticorps AHUS2, anticorps MCP, anticorps MIC10, anticorps TLX, anticorps TRA2.10, anticorps Mcp, anticorps CD46, anticorps CD46 molecule, anticorps CD46 antigen, complement regulatory protein, anticorps CD46 molecule, complement regulatory protein, anticorps membrane cofactor protein-like, anticorps CD46, anticorps Cd46, anticorps LOC100341359, anticorps LOC103789310

Sujet: AHUS2, CD46 antigen complement regulatory protein, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen

Poids moléculaire: 56-66 kDa

ID gène: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization