Annexin A2 anticorps

N° du produit ABIN3022160

Détail du produit anti-Annexin A2 anticorps

Antigène: Annexin A2 (ANXA2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Annexin A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant protein of human ANXA2

Isotype: IgG

Information d'application

Indications d'application: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C/-80 °C

Détails sur Annexin A2

Antigène: Annexin A2 (ANXA2)

Autre désignation: ANXA2 (ANXA2 Produits)

Synonymes: anticorps ANX2, anticorps ANX2L4, anticorps CAL1H, anticorps LIP2, anticorps LPC2, anticorps LPC2D, anticorps P36, anticorps PAP-IV, anticorps AW215814, anticorps Cal1h, anticorps p36, anticorps anx2, anticorps lip2, anticorps lpc2, anticorps cal1h, anticorps lpc2d, anticorps pap-i, anticorps anx2l4, anticorps MGC76145, anticorps ANXA2, anticorps anxa2, anticorps anxa2-a, anticorps anxa2-b, anticorps annexin A2, anticorps annexin A2 S homeolog, anticorps ANXA2, anticorps Anxa2, anticorps anxa2, anticorps anxa2.S

Sujet: Annexin A2 (ANXA2), also known as lipocortin II or calpactin-1 heavy chain, is a 36 kDa member of the annexin superfamily that binds phospholipids and other proteins in a calcium-dependent manner via annexin repeats. Annexin A2 contains four such repeats through which it mediates protein-protein and protein-lipid interactions. It forms a constitutive heterotetramer with S100A10, acting as a bridge between the actin cytoskeleton, plasma membrane, and endocytotic vesicle machinery. Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SNARE complexes, RNA, and virus particles. Annexin A2 has also been shown to have receptor-like activity and is detected on the surface of macrophages and vascular endothelial cells where it mediates macrophage activation and Factor Xa signaling, respectively. Upregulation of annexin A2 at the cell surface is thought to be modulated by phosphorylation at Tyr23 by Src. Interestingly, phosphorylation at Tyr23 has recently been shown to be required for cell surface expression of annexin A2 where it mediates motility, invasiveness, and overall metastatic potential of certain pancreatic cancer cells. Annexin A2 has also been shown to be heavily phosphorylated on serine residues in response to PKC activation via a pleiotropic mechanism. For a complete list of curated phosphorylation sites on annexin A2, please see PhosphoSitePlus® at www.phosphosite.org.
Synonyms: ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV

ID gène: 302

UniProt: P07355

Pathways: S100 Proteins